The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

被引：461

作者：

Christofides, Anthos ^{[1
,2
,3
]}

Konstantinidou, Eirini ^{[1
,2
,3
]}

Jani, Chinmay ^{[2
,4
]}

Boussiotis, Vassiliki A. ^{[1
,2
,3
]}

机构：

[1] Harvard Med Sch, Div Hematol Oncol, Boston, MA 02215 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02215 USA

[3] Harvard Med Sch, Ctr Canc, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Mt Auburn Hosp, Dept Med, Cambridge, MA 02138 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 114卷

基金：

美国国家卫生研究院;

关键词：

PPAR; Metabolism; Inflammation; T cells; Myeloid cells; FATTY-ACID OXIDATION; REGULATE MACROPHAGE POLARIZATION; FOAM-CELL-FORMATION; RAT ADIPOSE-TISSUE; DELTA AGONIST; GENE-EXPRESSION; T-CELLS; MESSENGER-RNA; BETA/DELTA ACTIVATION; TRANSCRIPTION FACTOR;

D O I：

10.1016/j.metabol.2020.154338

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPAR alpha, PPAR gamma, and PPAR beta/6. PPAR alpha and PPAR6 are highly expressed in oxidative tissues and regulate genes involved in substrate delivery and oxidative phosphorylation (OXPHOS) and regulation of energy homeostasis. In contrast, PPAR gamma is more important in lipogenesis and lipid synthesis, with highest expression levels in white adipose tissue (WAT). In addition to tissues regulating whole body energy homeostasis, PPARs are expressed in immune cells and have an emerging critical role in immune cell differentiation and fate commitment. In this review, we discuss the actions of PPARs in the function of the innate and the adaptive immune system and their implications in immune-mediated inflammatory conditions. (C) 2020 Elsevier Inc. All rights reserved.

引用

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