Structure and total synthesis of cyclodidemnamide B, a cycloheptapeptide from the ascidian Didemnum molle

被引：14

作者：

Arrault, A ^{[1
]}

Witczak-Legrand, A ^{[1
]}

Gonzalez, P ^{[1
]}

Bontemps-Subielos, N ^{[1
]}

Banaigs, B ^{[1
]}

机构：

[1] Univ Perpignan, UMR 5054 CNRS, Ctr Phytopharm, F-66860 Perpignan, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 22期

关键词：

cycloheptapeptide; thiazole-containing peptide; ascidian; Didemnum molle;

D O I：

10.1016/S0040-4039(02)00693-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cycloheptapeptide. cyclodidemnamide B (1), has been isolated from the marine ascidian Didemnum molle, collected at Ibo island, Mozambique. The structure of the bisthiazole-containing macrocyclic peptide was initially assigned using 2D NMR analysis and data comparisons with cyclodidemnamide. The absolute configuration was deduced after hydrolysis and characterization of degradation residues by chiral HPLC analysis. The total synthesis served as an unambiguous structural and stereochemical proof. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4041 / 4044

页数：4

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