Incidence of primary ciliary dyskinesia in children with recurrent respiratory diseases

被引:51
作者
Chapelin, C
Coste, A
Reinert, P
Boucherat, M
Millepied, MC
Poron, F
Escudier, E
机构
[1] UNIV MED PARIS 06, DEPT HISTOL, CRETEIL, FRANCE
[2] UNIV MED PARIS 12, DEPT HISTOL, CRETEIL, FRANCE
[3] HOP INTERCOMMUNAL CRETEIL, DEPT OTOLARYNGOL, CRETEIL, FRANCE
[4] HOP INTERCOMMUNAL CRETEIL, DEPT PEDIAT, CRETEIL, FRANCE
[5] HOP INTERCOMMUNAL CRETEIL, ELECTRON MICROSCOPY LAB, CRETEIL, FRANCE
关键词
child; ciliary beat frequency; ciliary ultrastructure; recurrent respiratory tract infection;
D O I
10.1177/000348949710601008
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The goal of the study was to evaluate the incidence of primary ciliary dyskinesia (PCD) in children suffering from recurrent respiratory tract infections (RRIs) by means of a noninvasive method. Respiratory ciliated cells were collected by nasal brushing in 118 children (4.6 +/- 2.5 years) with RRIs. The ciliary beat frequency (CBF) was measured with a stroboscopic method, and when the CBF was abnormal, the ciliary ultrastructure was analyzed by a quantitative method. The CBF could be measured in 106 patients (90%) and was abnormal in 15 patients. The ciliary ultrastructure was found to be abnormal in 11 of 15 patients: PCD was diagnosed in 6 cases, and acquired ciliary defects were observed in the remaining 5 patients. Our conclusion, that PCD is rare but not exceptional (5.6%) in children with RRIs, justifies the systematic investigation of ciliated cells in such patients. For this purpose, nasal brushing can be used to sample ciliated cells even in young children.
引用
收藏
页码:854 / 858
页数:5
相关论文
共 26 条
[11]  
ESCALIER D, 1982, BIOL CELL, V44, P271
[12]   DISSIMILAR EXPRESSION OF AXONEMAL ANOMALIES IN RESPIRATORY CILIA AND SPERM FLAGELLA IN INFERTILE MEN [J].
ESCUDIER, E ;
ESCALIER, D ;
PINCHON, MC ;
BOUCHERAT, M ;
BERNAUDIN, JF ;
FLEURYFEITH, J .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (03) :674-679
[13]  
ESCUDIER E, 1987, EUR J RESPIR DIS, V70, P180
[14]   NORMAL AXONEMAL STRUCTURE AND FUNCTION IN KARTAGENERS-SYNDROME - AN EXPLICABLE PARADOX [J].
GREENSTONE, M ;
RUTMAN, A ;
PAVIA, D ;
LAWRENCE, D ;
COLE, PJ .
THORAX, 1985, 40 (12) :956-957
[15]   NORMAL CILIARY ULTRASTRUCTURE IN CHILDREN WITH KARTAGENERS SYNDROME [J].
HERZON, FS ;
MURPHY, S .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1980, 89 (01) :81-83
[16]  
HOWELL JT, 1980, ARCH PATHOL LAB MED, V104, P52
[17]   ABNORMALITIES OF BRONCHIAL CILIA IN PATIENTS WITH CHRONIC-BRONCHITIS - AN ULTRASTURCTURAL AND QUANTITATIVE-ANALYSIS [J].
LUNGARELLA, G ;
FONZI, L ;
ERMINI, G .
LUNG, 1983, 161 (03) :147-156
[18]   PRIMARY AND SECONDARY CILIARY DYSKINESIA [J].
MYGIND, N ;
PEDERSEN, M ;
NIELSEN, MH .
ACTA OTO-LARYNGOLOGICA, 1983, 95 (5-6) :688-694
[19]  
PETRUSON B, 1987, ARCH OTOLARYNGOL, V113, P1294
[20]  
PIPKORN U, 1988, EUR RESPIR J, V1, P856