Risk factors for the isolation of multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa:: a systematic review of the literature

被引:233
作者
Falagas, M. E.
Kopterides, P.
机构
[1] Alfa Inst Biomed Sci, Athens 15123, Greece
[2] Henry Dunant Hosp, Dept Med, Athens, Greece
[3] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
[4] Attikon Univ Hosp, Crit Care Dept, Athens, Greece
关键词
multi-drug resistant Gram-negative bacteria; Acinetobacter baumannii; pseudomonas aeruginosa; risk factors;
D O I
10.1016/j.jhin.2006.04.015
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
An understanding of the epidemiology of multi-drug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections is necessary in order to develop strategies to curtail their spread. For this purpose, the evidence linking the isolation of MDR A. baumannii and P. aeruginosa with specific risk factors was evaluated. PubMed was searched for the 20-year period from September 1985 to September 2005, and eligible studies were considered to be those that: (1) linked the isolation of A. baumannii and P. aeruginosa with specific risk factors; (2) described the characteristics of the affected patients in detail; and (3) provided data on the antibiotic resistance profile of the isolated micro-organisms. Fifty-five studies were found referring to A. baumannii (28 with case-control methodology and 27 outbreak investigations without case-control methodology), and 42 studies were found referring to P. aeruginosa (25 with case-control methodology and 17 outbreak investigations without case-control methodology). Although heterogeneous study designs and investigated risk factors limited this analysis, it was concluded that acquisition and spread of these micro-organisms appear to be related to a large number of variables. Among the most important were deficiencies in the implementation of infection control guidelines and the use of broad-spectrum antibiotics. Use of carbapenems and third-generation cephalosporins appear to be related to the development of an MDR phenotype by A. baumannii, while carbapenems and fluoroquinolones are implicated in MDR P. aeruginosa. The diversity of risk factors associated with the development of MDR A. baumannii and P. aeruginosa suggests that a separate outbreak investigation should be performed in each hospital setting. The development of innovative control strategies is needed in order to limit the spread of these pathogens. (c) 2006 The Hospital Infection Society. Published by Elsevier Ltd. AIL rights reserved.
引用
收藏
页码:7 / 15
页数:9
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