Biodistribution studies

被引：3

作者：

Begent, RHJ

Bagshawe, KD

机构：

[1] Department of Clinical Oncology, Roy. Free Hosp. School of Medicine, London

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1996年 / 22卷 / 03期

关键词：

antibody therapy; ADEPT; gamma camera imaging; tumour enzyme measurements;

D O I：

10.1016/S0169-409X(96)00442-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ADEPT depends on selective delivery of enzyme to tumour. We have used radiolabelled antibody-enzyme conjugate and gamma camera imaging to assess enzyme delivery to tumour and normal tissues. Comparison with direct enzyme measurements in plasma confirms the presence of high tumour to normal tissue ratios in man at the time when prodrug is given. This makes a sound basis for successful ADEPT.

引用

页码：325 / 329

页数：5

共 4 条

[1] ANTIBODY DISTRIBUTION AND DOSIMETRY IN PATIENTS RECEIVING RADIOLABELED ANTIBODY THERAPY FOR COLORECTAL-CANCER [J].

BEGENT, RHJ ;

LEDERMANN, JA ;

GREEN, AJ ;

BAGSHAWE, KD ;

RIGGS, SJ ;

SEARLE, F ;

KEEP, PA ;

ADAM, T ;

DALE, RG ;

GLASER, MG .

BRITISH JOURNAL OF CANCER, 1989, 60 (03) :406-412

[2] ACCURATE QUANTIFICATION OF I-131 DISTRIBUTION BY GAMMA-CAMERA IMAGING [J].

GREEN, AJ ;

DEWHURST, SE ;

BEGENT, RHJ ;

BAGSHAWE, KD ;

RIGGS, SJ .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1990, 16 (4-6) :361-365

[3] RADIOIMMUNOTHERAPY OF METASTATIC COLORECTAL TUMORS WITH IODINE-131-LABELED ANTIBODY TO CARCINOEMBRYONIC ANTIGEN - PHASE I/II STUDY WITH COMPARATIVE BIODISTRIBUTION OF INTACT AND F(AB')(2) ANTIBODIES [J].

LANE, DM ;

EAGLE, KF ;

BEGENT, RHJ ;

HOPESTONE, LD ;

GREEN, AJ ;

CASEY, JL ;

KEEP, PA ;

KELLY, AMB ;

LEDERMANN, JA ;

GLASER, MG ;

HILSON, AJW .

BRITISH JOURNAL OF CANCER, 1994, 70 (03) :521-525

[4]

NAPIER MJ, 1996, IN PRESS BR J CANC

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