FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging

被引：40

作者：

Ji, Feng ^{[1
]}

Jin, Xi ^{[1
]}

Jiao, Chun-Hua ^{[1
]}

Xu, Qin-Wei ^{[1
]}

Wang, Zi-Wei ^{[1
]}

Chen, Yue-Liang ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Dept Digest Dis, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 18期

关键词：

Gastric cancer; FAT10; Mutant p53; Prognosis; GENE; MUTATIONS; IDENTIFICATION; EXPRESSION;

D O I：

10.3748/wjg.15.2228

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the role of FAT10 and mutant p53 in the pathogenesis, severity and prognosis of gastric cancer. METHODS: FAT10, mutant p53 mRNA and protein levels were measured by reverse transcription (RT)-PCR and immunohistochemistry in gastric cancer tissue (n = 62), tumor-adjacent tissue (n = 62) and normal gastric tissue (n = 62). Relation of FAT10 and mutant p53 expression with clinicopathological features and clinical outcomes of gastric cancer patients were analyzed. RESULTS: The FAT10, mutant p53 mRNA and protein levels were significantly higher in gastric cancer than in its adjacent and normal tissue. The FAT10 and mutant p53 levels in gastric cancer tissue were significantly correlated with lymph node metastasis and tumor, nodes, metastasis (TNM) staging. Moreover, the high FAT10 level was associated with the overall survival rate of patients. Multivariate Cox-proportional hazards model analysis showed that mRNA and protein levels of FAT10 and mutant p53, lymph node metastasis, distant metastasis and TNM stage were the independent prognostic factors for gastric cancer. CONCLUSION: FAT10 may be involved in gastric carcinogenesis, and is a potential marker for the prognosis of gastric cancer patients. FAT10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer. (C) 2009 The WIG Press and Baishideng. All rights reserved.

引用

页码：2228 / 2233

页数：6

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