Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives

被引：287

作者：

Amr, Abdel-Galil E. ^{[1
]}

Mohamed, Ashraf M. ^{[1
]}

Mohamed, Salwa F. ^{[1
]}

Abdel-Hafez, Nagla A. ^{[1
]}

Hammam, Abu El-Fotooh G. ^{[1
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 16期

关键词：

nitrobenzosuberone; pyranes; pyrimidinethiones; pyrazoles; anticancer activity;

D O I：

10.1016/j.bmc.2006.04.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A series of pyridine, pyrane, and pyrimidine derivatives (2-11) were newly synthesized using nitrobenzosuberone 1 as a starting material. The antitumor activities of the synthesized compounds were evaluated utilizing 59 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast, prostate as well as kidney. Some of the tested compounds especially 2, 3, 4c, 6, 7, 9b, 10a, and 11 exhibited better in vitro antitumor activities at low concentration (log(10) GI(50) = -4.7) against the used human tumor cell lines. Additionally, compounds 3, 4c, 6, 7, and 9b were highly selective to inhibit leukemia cell lines. The detailed synthesis, spectroscopic data and antitumor properties for the synthesized compounds were reported. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5481 / 5488

页数：8

共 23 条

[1]

Synthesis and investigation of a new cyclo (Nα-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity [J].