Mind the GAP: Wnt steps onto the mTORC1 train

被引：31

作者：

Choo, Andrew Y.

Roux, Philippe P.

Blenis, John ^{[2
]}

机构：

[1] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

[2] Harvard Univ, Sch Med, Prog Biol & Biomed Sci, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CELL | 2006年 / 126卷 / 05期

关键词：

D O I：

10.1016/j.cell.2006.08.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TSC1/2 tumor-suppressor complex controls protein synthesis through the regulation of mTOR. In this issue of Cell, Inoki et al. (2006) report that the kinases GSK3 and AMPK cooperate in the activation of TSC2 to inhibit mTOR activity. Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling. This suggests that components of the mTOR pathway may be therapeutic targets for diseases linked to hyperactive Wnt signaling.

引用

收藏

页码：834 / 836

页数：3

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