3-[2-(pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: Agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype

被引：17

作者：

Castro, JL ^{[1
]}

Street, LJ ^{[1
]}

Guiblin, AR ^{[1
]}

Jelley, RA ^{[1
]}

Russell, MGN ^{[1
]}

Sternfeld, F ^{[1
]}

Beer, MS ^{[1
]}

Stanton, JA ^{[1
]}

Matassa, VG ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,RES LABS,NEUROSCI RES CTR,DEPT BIOCHEM,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 22期

关键词：

D O I：

10.1021/jm9704558

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3497 / 3500

页数：6

共 24 条

[21] SYNTHESIS AND SEROTONERGIC ACTIVITY OF N,N-DIMETHYL-2-[5-(1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL] ETHYLAMINE AND ANALOGS - POTENT AGONISTS FOR 5-HT1D RECEPTORS [J].

STREET, LJ ;

BAKER, R ;

DAVEY, WB ;

GUIBLIN, AR ;

JELLEY, RA ;

REEVE, AJ ;

ROUTLEDGE, H ;

STERNFELD, F ;

WATT, AP ;

BEER, MS ;

MIDDLEMISS, DN ;

NOBLE, AJ ;

STANTON, JA ;

SCHOLEY, K ;

HARGREAVES, RJ ;

SOHAL, B ;

GRAHAM, MI ;

MATASSA, VG .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1799-1810

[22] EXPRESSION OF SEROTONIN RECEPTOR MESSENGER-RNAS IN BLOOD-VESSELS [J].

ULLMER, C ;

SCHMUCK, K ;

KALKMAN, HO ;

LUBBERT, H .

FEBS LETTERS, 1995, 370 (03) :215-221

[23]

VELDMAN SA, 1992, MOL PHARMACOL, V42, P439

[24] HUMAN SEROTONIN-1D RECEPTOR IS ENCODED BY A SUBFAMILY OF 2 DISTINCT GENES - 5-HT(1D-ALPHA) AND 5-HT(1D-BETA) [J].

WEINSHANK, RL ;

ZGOMBICK, JM ;

MACCHI, MJ ;

BRANCHEK, TA ;

HARTIG, PR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3630-3634

← 1 2 3 →