New tools and concepts for modern organic synthesis

被引：232

作者：

Ley, SV ^{[1
]}

Baxendale, IR ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 08期

关键词：

D O I：

10.1038/nrd871

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of the general applications and approaches to synthesis using one such technology - solid-supported reagents - that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules.

引用

页码：573 / 586

页数：14

共 137 条

[1] RECENT DEVELOPMENTS IN THE APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS [J].