Impaired decision-making in Parkinson's disease

被引:157
作者
Mimura, M
Oeda, R
Kawamura, M
机构
[1] Showa Univ, Sch Med, Dept Neuropsychiat, Shinagawa Ku, Tokyo 1428666, Japan
[2] Univ Tokyo, Dept Grad Sch, Meguro Ku, Tokyo 1538902, Japan
[3] Showa Univ, Sch Med, Dept Neurol, Shinagawa Ku, Tokyo 1428666, Japan
关键词
Parkinson's disease; social cognition; decision-making; mind-reading; executive function;
D O I
10.1016/j.parkreldis.2005.12.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The present study demonstrated that individuals with Parkinson's disease display impairments in making profitable decisions, as evidenced by poorer performance on the Iowa Gambling Task relative to matched controls. The ability to make beneficial judgments solely correlates with ability to appropriately attribute internal mental-state to other people, as shown in a mind-reading task. However, decision-making ability for individuals with Parkinson's disease is not associated with effective execution, intellectual function or depressed mood. These findings offer a new perspective on the cognitive impairments that affect social living and adaptive decisions for individuals with Parkinson's disease. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:169 / 175
页数:7
相关论文
共 30 条
[1]   PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[2]  
Armstrong RA, 2003, J NEURAL TRANSM, V110, P1303, DOI 10.1007/s00702-003-0039-1
[3]   Exploring the neurological substrate of emotional and social intelligence [J].
Bar-On, R ;
Tranel, D ;
Denburg, NL ;
Bechara, A .
BRAIN, 2003, 126 :1790-1800
[4]   Another advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger syndrome [J].
BaronCohen, S ;
Jolliffe, T ;
Mortimore, C ;
Robertson, M .
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 1997, 38 (07) :813-822
[5]   Emotion, decision making and the orbitofrontal cortex [J].
Bechara, A ;
Damasio, H ;
Damasio, AR .
CEREBRAL CORTEX, 2000, 10 (03) :295-307
[6]   INSENSITIVITY TO FUTURE CONSEQUENCES FOLLOWING DAMAGE TO HUMAN PREFRONTAL CORTEX [J].
BECHARA, A ;
DAMASIO, AR ;
DAMASIO, H ;
ANDERSON, SW .
COGNITION, 1994, 50 (1-3) :7-15
[7]   Deciding advantageously before knowing the advantageous strategy [J].
Bechara, A ;
Damasio, H ;
Tranel, D ;
Damasio, AR .
SCIENCE, 1997, 275 (5304) :1293-1295
[8]   Decision-making impairments in patients with Parkinson's disease [J].
Brand, M ;
Labudda, K ;
Kalbe, E ;
Hilker, R ;
Emmans, D ;
Fuchs, G ;
Kessler, J ;
Markowitsch, HJ .
BEHAVIOURAL NEUROLOGY, 2004, 15 (3-4) :77-85
[9]   COGNITIVE FUNCTION IN PARKINSONS-DISEASE - FROM DESCRIPTION TO THEORY [J].
BROWN, RG ;
MARSDEN, CD .
TRENDS IN NEUROSCIENCES, 1990, 13 (01) :21-29
[10]   L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease [J].
Cools, R ;
Barker, RA ;
Sahakian, BJ ;
Robbins, TW .
NEUROPSYCHOLOGIA, 2003, 41 (11) :1431-1441