Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

被引:185
作者
Greene, WC [1 ]
Peterlin, BM
机构
[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Rosalind Russell Med Res Ctr, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[4] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA
[5] Univ Calif San Francisco, Dept Immunol, San Francisco, CA 94143 USA
关键词
D O I
10.1038/nm0702-673
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adequate control of HIV requires impairing the infection, replication and spread of the virus, no small task given the extraordinary capacity of HIV to exploit the cell's molecular machinery in the course of infection. Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV.
引用
收藏
页码:673 / 680
页数:8
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  • [31] Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    Garrus, JE
    von Schwedler, UK
    Pornillos, OW
    Morham, SG
    Zavitz, KH
    Wang, HE
    Wettstein, DA
    Stray, KM
    Côté, M
    Rich, RL
    Myszka, DG
    Sundquist, WI
    [J]. CELL, 2001, 107 (01) : 55 - 65
  • [32] DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    Geijtenbeek, TBH
    Kwon, DS
    Torensma, R
    van Vliet, SJ
    van Duijnhoven, GCF
    Middel, J
    Cornelissen, ILMHA
    Nottet, HSLM
    KewalRamani, VN
    Littman, DR
    Figdor, CG
    van Kooyk, Y
    [J]. CELL, 2000, 100 (05) : 587 - 597
  • [33] HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
    Geleziunas, R
    Xu, WD
    Takeda, K
    Ichijo, H
    Greene, WC
    [J]. NATURE, 2001, 410 (6830) : 834 - 838
  • [34] Structure-function relationships in HIV-1 Nef
    Geyer, M
    Fackler, OT
    Peterlin, BM
    [J]. EMBO REPORTS, 2001, 2 (07) : 580 - 585
  • [35] CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4+ T-cell depletion in human lymphoid tissue ex vivo
    Glushakova, S
    Münch, J
    Carl, S
    Greenough, TC
    Sullivan, JL
    Margolis, L
    Kirchhoff, F
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (21) : 10113 - 10117
  • [36] HIV-1 Vpr increases viral expression by manipulation of the cell cycle:: A mechanism for selection of Vpr in vivo
    Goh, WC
    Rogel, ME
    Kinsey, CM
    Michael, SF
    Fultz, PN
    Nowak, MA
    Hahn, BH
    Emerman, M
    [J]. NATURE MEDICINE, 1998, 4 (01) : 65 - 71
  • [37] ROLE OF CAPSID PRECURSOR PROCESSING AND MYRISTOYLATION IN MORPHOGENESIS AND INFECTIVITY OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1
    GOTTLINGER, HG
    SODROSKI, JG
    HASELTINE, WA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) : 5781 - 5785
  • [38] Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis
    Greenway, AL
    McPhee, DA
    Allen, K
    Johnstone, R
    Holloway, G
    Mills, J
    Azad, A
    Sankovich, S
    Lambert, P
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (06) : 2692 - 2702
  • [39] Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    Hanna, Z
    Kay, DG
    Rebai, N
    Guimond, A
    Jothy, S
    Jolicoeur, P
    [J]. CELL, 1998, 95 (02) : 163 - 175
  • [40] Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    Hazuda, DJ
    Felock, P
    Witmer, M
    Wolfe, A
    Stillmock, K
    Grobler, JA
    Espeseth, A
    Gabryelski, L
    Schleif, W
    Blau, C
    Miller, MD
    [J]. SCIENCE, 2000, 287 (5453) : 646 - 650