Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis

被引：47

作者：

Adlington, RM ^{[1
]}

Baldwin, JE ^{[1
]}

Pritchard, GJ ^{[1
]}

Spencer, KC ^{[1
]}

机构：

[1] Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(99)02078-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel di-substituted pyrimidinyl C-nucleosides have been synthesised using a flexible synthetic methodology. This methodology conveniently allows the synthesis of alpha and beta nucleosides, both of which are of biological interest. Reactive acetylenic ketones, derived from 2-deoxyribose, can be reacted with substituted amidines to give new families of C-nucleoside natural product analogues. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：575 / 578

页数：4

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