Direct monitoring of the asymmetric induction of solid-phase catalysis using circular dichroism:: Diamine-CuI-catalyzed asymmetric Henry reaction

被引：102

作者：

Arai, Takayoshi

Watanabe, Masahiko

Fujiwara, Akitsugu

Yokoyama, Naota

Yanagisawa, Akira

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Chiba 2638522, Japan

[2] Chiba Univ, Grad Sch Sci & Technol, Chiba 2638522, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 36期

关键词：

asymmetric catalysis; circular dichroism; combinatorial chemistry; high-throughput screening; solid-phase synthesis;

D O I：

10.1002/anie.200602255

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct approach: A new high-throughput screening system for analyzing the asymmetric induction in catalytic enantioselective synthesis couples solid-phase reactions with a circular dichroism detection system (see picture). Thus, direct monitoring of asymmetric induction without the need for purification or chromatographic analysis is obtained. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5978 / 5981

页数：4

共 46 条

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