Isotopically chiral probes for in situ high-throughput asymmetric reaction analysis

被引：64

作者：

Evans, MA ^{[1
]}

Morken, JP ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Venable & Kenan Labs, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 31期

关键词：

D O I：

10.1021/ja026703t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we disclose a high-throughput screening assay for in situ analysis of enantioselection. The assay makes use of enantioenriched probe substrates that are isotopically chiral by virtue of a 13C isotope label. Upon catalytic asymmetric transformation, the carbon labels in the pseudoenantiomeric reaction products are in alternate diastereotopic environments and therefore lead to unique resonances. Simple integration allows for calculation of conversion and enantioselection. Copyright © 2002 American Chemical Society.

引用

页码：9020 / 9021

页数：2

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