Ruthenium-catalyzed tandem olefin migration - aldol- and Mannich-type reactions in ionic liquid

被引：50

作者：

Yang, XF

Wang, MW

Varma, RS

Li, CJ

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

[2] US EPA, Risk Management Res Lab, Cincinnati, OH 45268 USA

[3] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2004年 / 214卷 / 01期

基金：

美国国家科学基金会;

关键词：

aldol- and Mannich-type reactions; ionic liquid; ruthenium catalyst; catalyst recycling;

D O I：

10.1016/j.molcata.2003.12.031

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the presence of a catalytic amount of RuCl(PPh3)(3), a cross-coupling of 3-buten-2-ol (2) with aldehydes and imines was developed via a tandem olefin migration-aldol-Mannich reaction in bmim[PF6]. With In(OAc)(3) as co-catalyst, alpha-vinylbenzyl alcohol (4) and aldehydes underwent similar coupling reactions. Compared with aqueous and other organic solvents, complementary diastereoselectivity was observed with ionic liquid as the solvent. The ionic liquid/catalyst system could be reused at least five times without loss of activity. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：147 / 154

页数：8

共 58 条

[1] A highly stereo-divergent Mannich-type reaction catalyzed by Bronsted acid in aqueous media [J].