The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease

被引：10

作者：

Costa-Mallen, P

Checkoway, H

Fishel, M

Cohen, AW

Smith-Weller, T

Franklin, GM

Swanson, PD

Costa, LG

机构：

[1] Univ Washington, Sch Publ Hlth & Community Med, Dept Environm Hlth, Seattle, WA 98105 USA

[2] Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA

[3] Univ Washington, Med Ctr, Dept Neurol, Seattle, WA 98195 USA

[4] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2000年 / 278卷 / 1-2期

关键词：

polymorphism; monoamine oxidase A gene; Parkinson's disease; cigarette smoke; association; interaction;

D O I：

10.1016/S0304-3940(99)00890-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously observed an association with Parkinson's (PD), and modification of the effect of smoking on PD, by a polymorphism of the monoamine oxidase B (MAO-B) gene. The A form of monoamine oxidase (MAO-A) shares with MAO-B many characteristics that could be relevant to PD, especially proneuroxicant bioactivation and dopamine metabolism. MAO-A is also inhibited by tobacco smoke, which bears an apparent protective effect on PD. We investigated the possibility that MAO-A genetic variants may also be involved in predisposition to PD and in modification of the effect of smoking. Three-hundred and seventy-one subjects - 145 idiopathic PD cases and 226 age/gender-matched controls - were genotyped for the EcoRV polymorphism of MAO-A gene which has been related to increased enzyme activity. MAO-A EcoRV polymorphism was neither significantly associated with PD nor did it modify the inverse relationship with smoking. These results suggest that the EcoRV polymorphism of MAO-A is not an important biomarker of PD risk. Published by Elsevier Science Ireland Ltd.

引用

页码：33 / 36

页数：4

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