Enantioselective alkylation of alanine-derived imines using quaternary ammonium catalysts.

被引：138

作者：

Lygo, B

Crosby, J

Peterson, JA

机构：

[1] Univ Salford, Dept Chem & Appl Chem, Salford M5 4WT, Lancs, England

[2] AstraZeneca, Process R&D, Macclesfield SK10 2NA, Cheshire, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(99)01836-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of N-anthracenylmethyl dihydrocinchonidinium bromide as a catalyst for the enantioselective alkylation of a series of alanine-derived imines is reported. Using solid K2CO3/KOH as the stochiometric base such alkylations can be achieved with enantiomeric excesses up to 87% allowing rapid access to alpha,alpha-dialkyl-alpha-amino acid esters. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：8671 / 8674

页数：4

共 30 条

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