The molecular basis of fibronectin-mediated bacterial adherence to host cells

被引:204
作者
Schwarz-Linek, U
Höök, M
Potts, JR
机构
[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England
[2] Texas A&M Univ, Syst Hlth Sci Ctr, Ctr Extracellular Matrix Biol, Inst Biosci & Technol, Houston, TX 77030 USA
关键词
D O I
10.1111/j.1365-2958.2004.04027.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many pathogenic Gram-positive bacteria produce cell wall-anchored proteins that bind to components of the extracellular matrix (ECM) of the host. These bacterial MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are thought to play a critical role in infection. One group of MSCRAMMs, produced by staphylococci and streptococci, targets fibronectin (Fn, a glycoprotein found in the ECM and body fluids of vertebrates) using repeats in the C-terminal region of the bacterial protein. These bacterial Fn-binding proteins (FnBPs) mediate adhesion to host tissue and bacterial uptake into non-phagocytic host cells. Recent studies on interactions between the host and bacterial proteins at the residue-specific level and on the mechanism of host cell invasion are providing a much clearer picture of these processes.
引用
收藏
页码:631 / 641
页数:11
相关论文
共 76 条
[1]   Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases [J].
Agerer, F ;
Michel, A ;
Ohlsen, K ;
Hauck, CR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) :42524-42531
[2]   Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteria [J].
Ahmed, S ;
Meghji, S ;
Williams, RJ ;
Henderson, B ;
Brock, JH ;
Nair, SP .
INFECTION AND IMMUNITY, 2001, 69 (05) :2872-2877
[3]  
AKIYAMA SK, 1985, J BIOL CHEM, V260, P3256
[4]   Intrinsically disordered protein [J].
Dunker, AK ;
Lawson, JD ;
Brown, CJ ;
Williams, RM ;
Romero, P ;
Oh, JS ;
Oldfield, CJ ;
Campen, AM ;
Ratliff, CR ;
Hipps, KW ;
Ausio, J ;
Nissen, MS ;
Reeves, R ;
Kang, CH ;
Kissinger, CR ;
Bailey, RW ;
Griswold, MD ;
Chiu, M ;
Garner, EC ;
Obradovic, Z .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2001, 19 (01) :26-59
[5]   Fibronectin binding protein and host cell tyrosine kinase are required for internalization of Staphylococcus aureus by epithelial cells [J].
Dziewanowska, K ;
Patti, JM ;
Deobald, CF ;
Bayles, KW ;
Trumble, WR ;
Bohach, GA .
INFECTION AND IMMUNITY, 1999, 67 (09) :4673-4678
[6]   CLONING AND EXPRESSION OF THE GENE FOR A FIBRONECTIN-BINDING PROTEIN FROM STAPHYLOCOCCUS-AUREUS [J].
FLOCK, JI ;
FROMAN, G ;
JONSSON, K ;
GUSS, B ;
SIGNAS, C ;
NILSSON, B ;
RAUCCI, G ;
HOOK, M ;
WADSTROM, T ;
LINDBERG, M .
EMBO JOURNAL, 1987, 6 (08) :2351-2357
[7]   Reconsideration of the role of fibronectin binding in endocarditis caused by Staphylococcus aureus [J].
Flock, JI ;
Hienz, SA ;
Heimdahl, A ;
Schennings, T .
INFECTION AND IMMUNITY, 1996, 64 (05) :1876-1878
[8]   Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus [J].
Fowler, T ;
Johansson, S ;
Wary, KK ;
Höök, M .
CELLULAR MICROBIOLOGY, 2003, 5 (06) :417-426
[9]   Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell β1 integrins [J].
Fowler, T ;
Wann, ER ;
Joh, D ;
Johansson, SA ;
Foster, TJ ;
Höök, M .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2000, 79 (10) :672-679
[10]  
FROMAN G, 1987, J BIOL CHEM, V262, P6564