Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

被引：603

作者：

Chekulaeva, Marina ^{[1
]}

Filipowicz, Witold ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 03期

关键词：

MESSENGER-RNA DEGRADATION; C VIRUS-RNA; TRANSLATION INITIATION; PROTEIN-SYNTHESIS; LET-7; MICRORNA; CAENORHABDITIS-ELEGANS; ZEBRAFISH MIR-430; FAMILY PROTEINS; GENE-REGULATION; GW BODIES;

D O I：

10.1016/j.ceb.2009.04.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.

引用

页码：452 / 460

页数：9

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