Polyamines reduces lipid peroxidation induced by different pro-oxidant agents

被引：197

作者：

Bellé, NAV ^{[1
]}

Dalmolin, GD ^{[1
]}

Fonini, G ^{[1
]}

Rubin, MA ^{[1
]}

Rocha, JBT ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

BRAIN RESEARCH | 2004年 / 1008卷 / 02期

关键词：

polyamine; scavenger; free radical; antioxidant; lipid peroxidation;

D O I：

10.1016/j.brainres.2004.02.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the free radical and/or aldehyde scavenger effects of polyamines spermine and spermidine on thiobarbituric acid reactive species (TBARS) production induced by QA. SNP, Fe+2/EDTA system and free Fe2+ in rat brain. Spermine and spermidine inhibited QA-induced TBARS production: however spermine was a better antioxidant than spermidine. Spermine also inhibited SNP-, Fe+2/EDTA- and free Fe2+-induced TBARS production, but had a modest effect. Spermidine, in turn, also discreetly inhibited SNP-, Fe+2/EDTA- and free Fe2+-induced TBARS production. In the presence of MK-801, QA-induced TBARS production was considerably more inhibited by polyamines. In addition, arcaine does not affect the reducer effect of polyamines. The present findings suggest that the observed effects of polyamines are not related to the activation of NMDA receptor but with their antioxidant and free radical scavenger properties. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：245 / 251

页数：7

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