Understanding the diversity of prions

被引：38

作者：

Aguzzi, A ^{[1
]}

机构：

[1] Univ Spital Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1038/ncb0404-290

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protein-only hypothesis proposes that prions propagate by imparting specific folds onto cellular proteins. This hypothesis has met with resistance, partly because of the observation that many phenotypically distinct prion 'strains' are known to exist in yeast and mammals. Recent work on yeast prions may help reconcile the occurrence of prion strains with the prion hypothesis.

引用

页码：290 / 292

页数：3

共 16 条

[1] vCJD tissue distribution and transmission by transfusion - a worst-case scenario coming true? [J].

Aguzzi, A ;

Glatzel, M .

LANCET, 2004, 363 (9407) :411-412

[2] Mammalian prion biology: One century of evolving concepts [J].

Aguzzi, A ;

Polymenidou, M .

CELL, 2004, 116 (02) :313-327

[3] Prion diseases - Cannibals and garbage piles [J].

Aguzzi, A ;

Heikenwalder, M .

NATURE, 2003, 423 (6936) :127-129

[4] Prion research: the next frontiers [J].

Aguzzi, A ;

Weissmann, C .

NATURE, 1997, 389 (6653) :795-798

[5] BSE priors propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein [J].

Asante, EA ;

Linehan, JM ;

Desbruslais, M ;

Joiner, S ;

Gowland, I ;

Wood, AL ;

Welch, J ;

Hill, AF ;

Lloyd, SE ;

Wadsworth, JDF ;

Collinge, J .

EMBO JOURNAL, 2002, 21 (23) :6358-6366

[6] Conformational diversity in a yeast prion dictates its seeding specificity [J].

Chien, P ;

Weissman, JS .

NATURE, 2001, 410 (6825) :223-227

[7]

Derkatch IL, 1996, GENETICS, V144, P1375

[8] HOST-GENOTYPE AND AGENT EFFECTS IN SCRAPIE INCUBATION - CHANGE IN ALLELIC INTERACTION WITH DIFFERENT STRAINS OF AGENT [J].

DICKINSON, AG ;

MEIKLE, VMH .

MOLECULAR AND GENERAL GENETICS, 1971, 112 (01) :73-+

[9] Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease [J].

Glatzel, M ;

Abela, E ;

Maissen, M ;

Aguzzi, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (19) :1812-1820

[10] Protein-only transmission of three yeast prion strains [J].

King, CY ;

Diaz-Avalos, R .

NATURE, 2004, 428 (6980) :319-323

← 1 2 →