Enantioselective allylic alkylation using polymer-supported palladium catalysts

被引:55
作者
Hallman, K [1 ]
Macedo, E [1 ]
Nordström, K [1 ]
Moberg, C [1 ]
机构
[1] Royal Inst Technol, Dept Chem, SE-10044 Stockholm, Sweden
基金
瑞典研究理事会;
关键词
D O I
10.1016/S0957-4166(99)00416-4
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Chiral 2'-(4",5"-dihydro-2"-oxazolyl)-6'-(1-hydroxylalkyl)pyridines were grafted via ester-linkages directly to cross-linked polystyrene and to polyethyleneglycol-containing resins TentaGel and ArgoGel functionalized with carboxylic acid groups or via spacers containing a carboxylic acid group. The polymeric ligands were used in the palladium-catalyzed substitution of rac-1,3-diphenyl-2-propenyl acetate with dimethyl malonate. The enantioselectivities (up to 80% ee) were similar to those observed employing an analogous monomeric catalyst. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4037 / 4046
页数:10
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