Enantioselective allylic alkylation using polymer-supported palladium catalysts

被引：55

作者：

Hallman, K ^{[1
]}

Macedo, E ^{[1
]}

Nordström, K ^{[1
]}

Moberg, C ^{[1
]}

机构：

[1] Royal Inst Technol, Dept Chem, SE-10044 Stockholm, Sweden

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 20期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/S0957-4166(99)00416-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral 2'-(4",5"-dihydro-2"-oxazolyl)-6'-(1-hydroxylalkyl)pyridines were grafted via ester-linkages directly to cross-linked polystyrene and to polyethyleneglycol-containing resins TentaGel and ArgoGel functionalized with carboxylic acid groups or via spacers containing a carboxylic acid group. The polymeric ligands were used in the palladium-catalyzed substitution of rac-1,3-diphenyl-2-propenyl acetate with dimethyl malonate. The enantioselectivities (up to 80% ee) were similar to those observed employing an analogous monomeric catalyst. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4037 / 4046

页数：10

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