A neglected epidemic: fungal infections in HIV/AIDS

被引：285

作者：

Armstrong-James, Darius ^{[1
]}

Meintjes, Graeme ^{[2
]}

Brown, Gordon D. ^{[2
,3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Imperial Fungal Dis Grp, Dept Infect Dis & Immun, Hammersmith Hosp, London W12 0NN, England

[2] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[3] Univ Aberdeen, Aberdeen Fungal Grp, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 03期

关键词：

HIV; fungal infection; immunity; AIDS; mycoses; PNEUMOCYSTIS-JIROVECII PNEUMONIA; PENICILLIUM-MARNEFFEI INFECTION; RECONSTITUTION INFLAMMATORY SYNDROME; HIV-POSITIVE PATIENTS; CRYPTOCOCCAL MENINGITIS; PROTECTIVE IMMUNITY; CEREBROSPINAL-FLUID; AMPHOTERICIN-B; CELL RESPONSE; HISTOPLASMOSIS;

D O I：

10.1016/j.tim.2014.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths annually from IFIs, accounting for 50% of all AIDS-related death. A historic failure to focus efforts on the IFIs that kill so many HIV patients has led to fundamental flaws in the management of advanced HIV infection. This review, based on the EMBO AIDS-Related Mycoses Workshop in Cape Town in July 2013, summarizes the current state of the-art in AIDS-related mycoses, and the key action points required to improve outcomes from these devastating infections.

引用

收藏

页码：120 / 127

页数：8

相关论文

共 74 条

[1]

Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis Pneumonia [J].

An, Ping ;

Li, Rongling ;

Wang, Ji Ming ;

Yoshimura, Teizo ;

Takahashi, Munehisa ;

Samudralal, Ram ;

O'Brien, Stephen J. ;

Phair, John ;

Goedert, James J. ;

Kirk, Gregory D. ;

Troyer, Jennifer L. ;

Sezgin, Efe ;

Buchbinder, Susan P. ;

Donfield, Sharyne ;

Nelson, George W. ;

Winkler, Cheryl A. .

PLOS GENETICS, 2011, 7 (10)

[2]

[Anonymous], COCHRANE DATABASE SY

[3]

A prognostic scoring tool for identification of patients at high and low risk of death from HIV-associated Pneumocystis jirovecii pneumonia [J].

Armstrong-James, D. ;

Copas, A. J. ;

Walzer, P. D. ;

Edwards, S. G. ;

Miller, R. F. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2011, 22 (11) :628-634

[4]

A trial of caspofungin salvage treatment in PCP pneumonia [J].

Armstrong-James, Darius ;

Stebbing, Justin ;

John, Laurence ;

Murungi, Andrew ;

Bower, Mark ;

Gazzard, Brian ;

Nelson, Mark .

THORAX, 2011, 66 (06) :537-538

[5]

Decreasing incidence of cryptococcal meningitis in West Africa in the era of highly active antiretroviral therapy [J].

Bamba, Sanata ;

Lortholary, Olivier ;

Sawadogo, Adrien ;

Millogo, Athanase ;

Guiguemde, Robert T. ;

Bretagne, Stephane .

AIDS, 2012, 26 (08) :1039-1041

[6]

Anti-CD3 Antibody Decreases Inflammation and Improves Outcome in a Murine Model of Pneumocystis Pneumonia [J].

Bhagwat, Samir P. ;

Wright, Terry W. ;

Gigliotti, Francis .

JOURNAL OF IMMUNOLOGY, 2010, 184 (01) :497-502

[7]

Early Versus Delayed Antiretroviral Therapy and Cerebrospinal Fluid Fungal Clearance in Adults With HIV and Cryptococcal Meningitis [J].

Bisson, Gregory P. ;

Molefi, Mooketsi ;

Bellamy, Scarlett ;

Thakur, Rameshwari ;

Steenhoff, Andrew ;

Tamuhla, Neo ;

Rantleru, Tumelo ;

Tsimako, Irene ;

Gluckman, Stephen ;

Ravimohan, Shruthi ;

Weissman, Drew ;

Tebas, Pablo .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (08) :1165-1173

[8]

Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study [J].

Boulware, David R. ;

Meya, David B. ;

Bergemann, Tracy L. ;

Wiesner, Darin L. ;

Rhein, Joshua ;

Musubire, Abdu ;

Lee, Sarah J. ;

Kambugu, Andrew ;

Janoff, Edward N. ;

Bohjanen, Paul R. .

PLOS MEDICINE, 2010, 7 (12)

[9]

Histoplasmosis in HIV-positive patients in Ceara, Brazil: clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates [J].

Brilhante, Raimunda S. N. ;

Fechine, Maria A. B. ;

Mesquita, Jaco R. L. ;

Cordeiro, Rossana A. ;

Rocha, Marcos F. G. ;

Monteiro, Andre J. ;

Lima, Rita A. C. ;

Caetano, Erica P. ;

Pereira, Juliana F. ;

Castelo-Branco, Debora S. C. M. ;

Camargo, Zoilo P. ;

Sidrim, Jose J. C. .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2012, 106 (08) :484-488

[10]

Hidden Killers: Human Fungal Infections [J].

Brown, Gordon D. ;

Denning, David W. ;

Gow, Neil A. R. ;

Levitz, Stuart M. ;

Netea, Mihai G. ;

White, Theodore C. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (165)

← 1 2 3 4 5 6 7 8 →