Cytokine, Sickness Behavior, and Depression

被引:580
作者
Dantzer, Robert [1 ]
机构
[1] Univ Illinois, Integrat Immunol & Behav Program, Urbana, IL 61801 USA
基金
美国国家卫生研究院;
关键词
Inflammation; Cytokine; Sickness; Depression; Interleukin-1; Tumor necrosis factor; Brain; Behavior; RECEPTOR ACCESSORY PROTEIN; FUNCTIONAL ANATOMICAL ANALYSIS; II INTERLEUKIN-1 RECEPTORS; INTERFERON-ALPHA THERAPY; CHRONIC HEPATITIS-C; RAT-BRAIN; MAJOR DEPRESSION; MOUSE-BRAIN; SYSTEMIC INFLAMMATION; DEFICIENT MICE;
D O I
10.1016/j.iac.2009.02.002
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The psychologic; and behavioral components of sickness represent, together with fever response and associated neuroendocrine changes, a highly organized strategy of the organism to fight infection. This strategy, referred to as sickness behavior, is triggered by the proinflammatory cytokines produced by activated cells of the innate immune system in contact with specific pathogen-associated molecular patterns (PAMPs). Interleukin-1 and other cytokines act on the brain via (1) a neural route represented by the primary afferent neurons that innervate the body site where the infectious process takes place and (2) a humoral pathway that involves the production of proinflammatory cytokines. This article presents the current knowledge on the way this communication system is organized and regulated and the implications of these advances for understanding brain physiology and pathology.
引用
收藏
页码:247 / +
页数:20
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