Pulmonary complications of immune reconstitution inflammatory syndromes in HIV-infected patients

被引：20

作者：

Crothers, Kristina ^{[1
]}

Huang, Laurence ^{[2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Pulm & Crit Care Med Sect, New Haven, CT 06510 USA

[2] Univ Calif San Francisco, San Francisco Gen Hosp, Div Pulm & Crit Care Med, San Francisco, CA USA

[3] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, San Francisco, CA USA

来源：

RESPIROLOGY | 2009年 / 14卷 / 04期

关键词：

AIDS; antiretroviral therapy; highly active; HIV; immune reconstitution inflammatory syndrome; lung disease; ACTIVE ANTIRETROVIRAL THERAPY; PNEUMOCYSTIS-CARINII-PNEUMONIA; RISK-FACTORS; RESTORATION DISEASE; KAPOSI-SARCOMA; SOUTH-AFRICA; SARCOIDOSIS; TUBERCULOSIS; HAART; AIDS;

D O I：

10.1111/j.1440-1843.2008.01468.x

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Immune reconstitution inflammatory syndrome (IRIS) describes a paradoxical worsening of clinical status related to recovery of the immune system, as can occur after the initiation of highly active antiretroviral therapy (HAART) in HIV-infected patients. Most commonly, IRIS results from opportunistic infections that can unmask or develop paradoxical worsening following HAART. Cancers, autoimmune conditions and sarcoidosis have also been associated with IRIS. Pulmonary complications may be frequently encountered. This article reviews the types and clinical presentation of IRIS, with a focus on the pulmonary manifestations. Management and outcome of IRIS are considered.

引用

页码：486 / 494

页数：9

共 64 条

[1]

Adult Prevention and Treatment of Opportunistic Infections Guidelines Working Group, 2008, GUID PREV TREATM OPP, P1

[2] Coexistent sarcoidosis and HIV infection: an immunological paradox? [J].

Almeida, FA ;

Sager, JS ;

Eiger, G .

JOURNAL OF INFECTION, 2006, 52 (03) :195-201

[3]

Barry S M, 2002, HIV Med, V3, P207, DOI 10.1046/j.1468-1293.2002.00115.x

[4] Immunological recovery and antiretroviral therapy in HIV-1 infection [J].

Battegay, M ;

Nuesch, R ;

Hirschel, B ;

Kaufmann, GR .

LANCET INFECTIOUS DISEASES, 2006, 6 (05) :280-287

[5] Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients [J].

Bourgarit, A ;

Carcelain, G ;

Martinez, V ;

Lascoux, C ;

Delcey, V ;

Gicquel, B ;

Vicaut, E ;

Lagrange, PH ;

Sereni, D ;

Autran, B .

AIDS, 2006, 20 (02) :F1-F7

[6] Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients [J].

Cheng, VCC ;

Ho, PL ;

Lee, RA ;

Chan, KS ;

Chan, KK ;

Woo, PCY ;

Lau, SKP ;

Yuen, KY .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2002, 21 (11) :803-809

[7]

Cheng VCC, 2001, EUR J CLIN MICROBIOL, V20, P402

[8] Immunorestitution disease involving the innate and adaptive response [J].

Cheng, VCC ;

Yuen, KY ;

Chan, WM ;

Wong, SSY ;

Ma, ESK ;

Chan, RMT .

CLINICAL INFECTIOUS DISEASES, 2000, 30 (06) :882-892

[9] Do CD8+CD25+cells predict immune reconstitution syndrome in HIV-positive patients who begin HAART? [J].

Cianchetta-Sivori, Malena ;

Raso, Sandra ;

Fernandez-Guerrero, Manuel ;

Gorgolas, Miguel ;

Garcia, Rosa .

AIDS, 2007, 21 (17) :2347-2349

[10] Lymphoma developing shortly after the onset of highly active antiretroviral therapy in HIV-infected patients [J].

Collazos, J ;

Ojanguren, J ;

Mayo, J ;

Martínez, E ;

Ibarra, S .

AIDS, 2002, 16 (09) :1304-1306

← 1 2 3 4 5 6 7 →