Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery

被引：173

作者：

Chen, Xueyun ^{[1
]}

Fan, Ming ^{[1
]}

Tan, Huaping ^{[1
]}

Ren, Bowen ^{[1
]}

Yuan, Guoliang ^{[1
]}

Jia, Yang ^{[1
]}

Li, Jianliang ^{[1
]}

Xiong, Dangsheng ^{[1
]}

Xing, Xiaodong ^{[2
]}

Niu, Xiaohong ^{[3
]}

Hu, Xiaohong ^{[4
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Mat Sci & Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[3] Nanjing Hosp Integrated Tradit Chinese & Western, Dept Luoli, Nanjing 210014, Jiangsu, Peoples R China

[4] Jinling Inst Technol, Sch Mat Engn, Nanjing 211169, Jiangsu, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 101卷

关键词：

Hydrogel; Magnetic microspheres; 5-Fluorouracil; Self-healing; Drug delivery; ENHANCED PHOTOCATALYTIC DEGRADATION; IN-VITRO; SONOCHEMICAL SYNTHESIS; NANOCOMPOSITES; CELL; POLLUTANT; SCAFFOLD; RELEASE; SYSTEM; BLEND;

D O I：

10.1016/j.msec.2019.04.012

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

In order to broaden the abilities of injectable hydrogel scaffolds, a self-healing chitosan/alginate hydrogel encapsulated with magnetic gelatin microspheres (MGMs) was prepared for anti-cancer drug delivery and soft tissue engineering. The hydrogel was formulated by cross-linking carboxyethyl chitosan (CEC) and oxidized alginate (OAlg) via the Schiff-base reaction. To strengthen the mechanical and biological capabilities of hydrogel, MGMs containing 5-fluorouracil (5-Fu) were prepared by an emulsion cross-linking method. In vitro gelation time, swelling ratio, degradation, compressive modulus and rheological behaviors were tested to monitor the effect of MGMs on the CEC-OAlg hydrogel. With a concentration of 30 mg/mL MGMs, the composite hydrogel provided with the suitable performance and showed excellent self-healing ability under physiological condition. Moreover, this composite hydrogel showed the sustained in vitro drug release compared with control MGMs and CEC-OAlg hydrogel. Our results demonstrated that this magnetic and self-healing CEC-OAlg hydrogel scaffold encapsulated MGMs containing 5-Fu was expected to be a platform for drug delivery and soft tissue engineering.

引用

页码：619 / 629

页数：11

共 57 条

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