Efficient room temperature copper(I) mediated 5-endo radical cyclisations

被引：55

作者：

Clark, AJ ^{[1
]}

Dell, CP

Ellard, JM

Hunt, NA

McDonagh, JP

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(99)01806-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of bromo-enamides with catalytic Cu(Me-6-trien)Br at room temperature furnishes regioisomeric mixtures of unsaturated pyrrolidinones in a highly efficient manner via an initial 5-endo radical cyclisation reaction followed by an oxidation and elimination of H+. Bromo-enamide 3f furnishes the beta-lactam via a 4-exo cyclisation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8619 / 8623

页数：5

共 22 条

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