Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

被引：94

作者：

Carvalho, Cristiane de Souza ^{[1
,3
]}

Daum, Nicole ^{[1
,3
]}

Lehr, Claus-Michael ^{[1
,2
,3
]}

机构：

[1] Univ Saarland, Helmholtz Inst Pharmaceut Res Saarland HIPS, D-66123 Saarbrucken, Germany

[2] Univ Saarland, Dept Biopharmaceut & Pharmaceut Technol, D-66123 Saarbrucken, Germany

[3] Helmholtz Ctr Infect Res HZI, Braunschweig, Germany

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2014年 / 75卷

关键词：

3D cell culture; Air-blood barrier; Particles; Challenge; Mucus; Surfactant; AIR-LIQUID INTERFACE; TRANSFERRIN-CONJUGATED LIPOSOMES; EPITHELIAL-CELL MONOLAYERS; DENDRITIC CELLS; HUMAN ALVEOLAR; INFLAMMATORY RESPONSE; RESPIRATORY-TRACT; TARGETED DELIVERY; DEFENSE-MECHANISM; MUCUS CLEARANCE;

D O I：

10.1016/j.addr.2014.05.014

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air-blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy by which that goal could be achieved. In this review we discuss currently available in vitro lung models, including some recent tissue-engineering approaches, as well as the challenges associated to implement such complex in vitro systems. Furthermore, we discuss available carrier technologies, often based on nanotechnology, to target specific regions of the lungs and to overcome the respective biological barriers, ideally resulting in safe and effective delivery to the desired pulmonary destination. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：129 / 140

页数：12

共 108 条

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ORIGIN AND KINETICS OF PULMONARY MACROPHAGES DURING AN INFLAMMATORY REACTION INDUCED BY INTRAVENOUS ADMINISTRATION OF HEAT-KILLED BACILLUS CALMETTE-GUERIN [J].