Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10

被引：70

作者：

Bae, NS

Swanson, MJ

Vassilev, A

Howard, BH

机构：

[1] NICHHD, Lab Mol & Growth Regulat, NIH, Bethesda, MD 20892 USA

[2] NICHHD, Lab Eukaryot Gene Regulat, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOCHEMISTRY | 2004年 / 135卷 / 06期

关键词：

HOXA10; SIRT2;

D O I：

10.1093/jb/mvh084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone deacetylases are required for transcriptional repression in eukaryotes. Saccharomyces cerevisiae has several histone deacetylases, of which ySir2p is the most conserved throughout evolution. Currently, there is no report on the interacting protein partner of a human Sir2 homolog, SIRT2. Here we show for the first time that SIRT2 interacts with the homeobox transcription factor, HOXA10, which was identified in a two-hybrid screen. Interactions were confirmed by co-immunoprecipitation from in vitro translations as well as in human cell-free extracts. Taken together with mouse knockout studies, our results raise the intriguing possibility that SIRT2 plays a role in mammalian development.

引用

页码：695 / 700

页数：6

共 30 条

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