Application of comparative biology in GO functional annotation: the mouse model

被引：9

作者：

Drabkin, Harold J. ^{[1
]}

Christie, Karen R. ^{[1
]}

Dolan, Mary E. ^{[1
]}

Hill, David P. ^{[1
]}

Ni, Li ^{[1
]}

Sitnikov, Dmitry ^{[1
]}

Blake, Judith A. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

MAMMALIAN GENOME | 2015年 / 26卷 / 9-10期

关键词：

ONTOLOGY; DMRT2;

D O I：

10.1007/s00335-015-9580-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gene Ontology (GO) is an important component of modern biological knowledge representation with great utility for computational analysis of genomic and genetic data. The Gene Ontology Consortium (GOC) consists of a large team of contributors including curation teams from most model organism database groups as well as curation teams focused on representation of data relevant to specific human diseases. Key to the generation of consistent and comprehensive annotations is the development and use of shared standards and measures of curation quality. The GOC engages all contributors to work to a defined standard of curation that is presented here in the context of annotation of genes in the laboratory mouse. Comprehensive understanding of the origin, epistemology, and coverage of GO annotations is essential for most effective use of GO resources. Here the application of comparative approaches to capturing functional data in the mouse system is described.

引用

页码：574 / 583

页数：10

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