Monastrol stabilises an attached low-friction mode of Eg5

被引：55

作者：

Crevel, IMTC ^{[1
]}

Alonso, MC ^{[1
]}

Cross, RA ^{[1
]}

机构：

[1] Marie Curie Res Inst, Oxted RH8 0TL, Surrey, England

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 11期

关键词：

D O I：

10.1016/j.cub.2004.05.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：R411 / R412

页数：2

共 12 条

[1]

COLE DG, 1994, J BIOL CHEM, V269, P22913

[2] Kinetic evidence for low chemical processivity in ncd and Eg5 [J].

Crevel, IMTC ;

Lockhart, A ;

Cross, RA .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (01) :160-170

[3] Interaction of the mitotic inhibitor monastrol with human kinesin Eg5 [J].

DeBonis, S ;

Simorre, JP ;

Crevel, I ;

Lebeau, L ;

Skoufias, DA ;

Blangy, A ;

Ebel, C ;

Gans, P ;

Cross, R ;

Hackney, DD ;

Wade, RH ;

Kozielski, F .

BIOCHEMISTRY, 2003, 42 (02) :338-349

[4] Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5 [J].

Kapoor, TM ;

Mayer, TU ;

Coughlin, ML ;

Mitchison, TJ .

JOURNAL OF CELL BIOLOGY, 2000, 150 (05) :975-988

[5] Switch-based mechanism of kinesin motors [J].

Kikkawa, M ;

Sablin, EP ;

Okada, Y ;

Yajima, H ;

Fletterick, RJ ;

Hirokawa, N .

NATURE, 2001, 411 (6836) :439-445

[6] Kinetics and motility of the Eg5 microtubule motor [J].

Lockhart, A ;

Cross, RA .

BIOCHEMISTRY, 1996, 35 (07) :2365-2373

[7] Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 [J].

Maliga, Z ;

Kapoor, TM ;

Mitchison, TJ .

CHEMISTRY & BIOLOGY, 2002, 9 (09) :989-996

[8] Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen [J].

Mayer, TU ;

Kapoor, TM ;

Haggarty, SJ ;

King, RW ;

Schreiber, SL ;

Mitchison, TJ .

SCIENCE, 1999, 286 (5441) :971-974

[9] Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin [J].

Okada, Y ;

Hirokawa, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :640-645

[10] ONE-DIMENSIONAL DIFFUSION OF MICROTUBULES BOUND TO FLAGELLAR DYNEIN [J].

VALE, RD ;

SOLL, DR ;

GIBBONS, IR .

CELL, 1989, 59 (05) :915-925

← 1 2 →