Synthesis and characterization of functional poly(γ-benzyl-L-glutamate) (PBLG) as a hydrophobic precursor

被引：60

作者：

Guo, Jinshan ^{[1
,2
]}

Huang, Yubin ^{[1
]}

Jing, Xiabin ^{[1
]}

Chen, Xuesi ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

POLYMER | 2009年 / 50卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Functionalization of PBLG; Click chemistry; Thiol-ene reaction; CHOLESTERIC MESOPHASE PROPERTIES; THERMOTROPIC POLYPEPTIDES; CLICK CHEMISTRY; L-GLUTAMATE); POLYMERS; COPOLYMERS; ACID; POLYMERIZATION; DERIVATIVES; BEHAVIOR;

D O I：

10.1016/j.polymer.2009.04.016

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Four kinds of functional poly(gamma-benzyl-L-glutamate) (PBLG) copolymers containing chloro, azido, allyl or propargyl groups on the side chains were synthesized through ester exchange reactions of PBLG with functional alcohols without any protection and de-protection process. Hydrolysis of PBLG, which was found during the ester exchange reaction under low ratios of alcohol to the repeat units of PBLG, was thoroughly investigated, and could be successfully depressed by addition of certain amount of benzyl alcohol to the reaction system. Click chemistry reactions of the azidized or propargylated copolymers, thiol-ene reaction of the allyllated copolymer were taken successfully, indicating that the functional groups on the copolymers were still reactive. Microspheres were also formed, which showed the potential application of the functional polymers as micro-carriers. Characterizations including H-1 NMR, C-13 NMR, FTIR, elemental analysis, DSC, TGA, ESEM, fluorescence microscope and SEC-MALS were taken. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2847 / 2855

页数：9

共 49 条

[1]

A versatile synthetic approach to polypeptide based rod-coil block copolymers by click chemistry [J].