Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolones

被引：18

作者：

Lange, UEW ^{[1
]}

机构：

[1] BASF AG, Combinatorial Chem, Agrochem Res, D-67056 Ludwigshafen, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 38期

关键词：

solid-phase synthesis; combinatorial chemistry; 4H-imidazolones; atropo-isomers;

D O I：

10.1016/S0040-4039(02)01400-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolones suitable for automation using the dehydration of a urea as the key-step is described. The novel method is compared with other reported procedures. Furthermore, the formation of imidazolone diastereoisomers containing a chiral C,N-axis is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6857 / 6860

页数：4

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