A general formalism for metabolic control analysis

被引：17

作者：

Ehlde, M ^{[1
]}

Zacchi, G ^{[1
]}

机构：

[1] LUND UNIV, DEPT CHEM ENGN 1, S-22100 LUND, SWEDEN

来源：

CHEMICAL ENGINEERING SCIENCE | 1997年 / 52卷 / 15期

关键词：

D O I：

10.1016/S0009-2509(97)00076-6

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.

引用

页码：2599 / 2606

页数：8

共 12 条

[1] USE OF IMPLICIT METHODS FROM GENERAL SENSITIVITY THEORY TO DEVELOP A SYSTEMATIC-APPROACH TO METABOLIC CONTROL .1. UNBRANCHED PATHWAYS [J].