The many facets of the Wilms' tumour gene, WT1

被引：287

作者：

Hohenstein, Peter ^{[1
]}

Hastie, Nicholas D. ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EX4 2XU, Midlothian, Scotland

来源：

HUMAN MOLECULAR GENETICS | 2006年 / 15卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/hmg/ddl196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the years, many apparently contradictory findings and functions have been ascribed to the protein product of the WT1 tumour suppressor gene. These include being a transcriptional activator or repressor, a function in transcription versus RNA metabolism, and these days even a function as oncogene or tumour suppressor gene. To fully understand the role of WT1 in different diseases and normal development, we will need to understand these contradictions. In this review, we will discuss the present state of knowledge and suggest that a role for WT1 in influencing the mesenchymal-epithelial state of cells might be a common function that could explain many of the previously described findings.

引用

页码：R196 / R201

页数：6

共 41 条

[1] The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron [J].

Bor, Yeou-cherng ;

Swartz, Jennifer ;

Morrison, Avril ;

Rekosh, David ;

Ladomery, Michael ;

Hammarskjold, Marie-Louise .

GENES & DEVELOPMENT, 2006, 20 (12) :1597-1608

[2] BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1 [J].

Carpenter, B ;

Hill, KJ ;

Charalambous, M ;

Wagner, KJ ;

Lahiri, D ;

James, DI ;

Andersen, JS ;

Schumacher, V ;

Royer-Pokora, B ;

Mann, M ;

Ward, A ;

Roberts, SGE .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (02) :537-549

[3] Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours [J].

Dallosso, AR ;

Hancock, AL ;

Brown, KW ;

Williams, AC ;

Jackson, S ;

Malik, K .

HUMAN MOLECULAR GENETICS, 2004, 13 (04) :405-415

[4] Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation [J].

Davies, JA ;

Ladomery, M ;

Hohenstein, P ;

Michael, L ;

Shafe, A ;

Spraggon, L ;

Hastie, N .

HUMAN MOLECULAR GENETICS, 2004, 13 (02) :235-246

[5] WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes [J].

Davies, RC ;

Calvio, C ;

Bratt, E ;

Larsson, SH ;

Lamond, AI ;

Hastie, ND .

GENES & DEVELOPMENT, 1998, 12 (20) :3217-3225

[6] Detection of a novel truncated WT1 transcript in human neoplasia [J].

Dechsukhum, C ;

Ware, JL ;

Ferreira-Gonzalez, A ;

Wilkinson, DS ;

Garrett, CT .

MOLECULAR DIAGNOSIS, 2000, 5 (02) :117-128

[7] The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis [J].

Gao, Fei ;

Maiti, Sourindra ;

Alam, Nargis ;

Zhang, Zhen ;

Deng, Jian Min ;

Behringer, Richard R. ;

Lecureuil, Charlotte ;

Guillou, Florian ;

Huff, Vicki .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (32) :11987-11992

[8] The receptor tyrosine kinase regulator sprouty1 is a target of the tumor suppressor WT1 and important for kidney development [J].

Gross, I ;

Morrison, DJ ;

Hyink, DP ;

Georgas, K ;

English, MA ;

Mericskay, M ;

Hosono, S ;

Sasson, D ;

Wilson, PD ;

Little, M ;

Licht, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :41420-41430

[9] AN INTERNAL DELETION WITHIN AN 11P13 ZINC FINGER GENE CONTRIBUTES TO THE DEVELOPMENT OF WILMS-TUMOR [J].

HABER, DA ;

BUCKLER, AJ ;

GLASER, T ;

CALL, KM ;

PELLETIER, J ;

SOHN, RL ;

DOUGLASS, EC ;

HOUSMAN, DE .

CELL, 1990, 61 (07) :1257-1269

[10] Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation [J].

Hammes, A ;

Guo, JK ;

Lutsch, G ;

Leheste, JR ;

Landrock, D ;

Ziegler, U ;

Gubler, MC ;

Schedl, A .

CELL, 2001, 106 (03) :319-329

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