The many facets of the Wilms' tumour gene, WT1

被引：287

作者：

Hohenstein, Peter ^{[1
]}

Hastie, Nicholas D. ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EX4 2XU, Midlothian, Scotland

来源：

HUMAN MOLECULAR GENETICS | 2006年 / 15卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/hmg/ddl196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the years, many apparently contradictory findings and functions have been ascribed to the protein product of the WT1 tumour suppressor gene. These include being a transcriptional activator or repressor, a function in transcription versus RNA metabolism, and these days even a function as oncogene or tumour suppressor gene. To fully understand the role of WT1 in different diseases and normal development, we will need to understand these contradictions. In this review, we will discuss the present state of knowledge and suggest that a role for WT1 in influencing the mesenchymal-epithelial state of cells might be a common function that could explain many of the previously described findings.

引用

页码：R196 / R201

页数：6

共 41 条

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