An insight on medicinal attributes of 1,2,4-triazoles

被引：237

作者：

Aggarwal, Ranjana ^{[1
,2
]}

Sumran, Garima ^{[3
]}

机构：

[1] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India

[2] CSIR Natl Inst Sci Technol & Dev Studies, New Delhi, India

[3] DAV Coll Lahore, Dept Chem, Ambala City 134003, Haryana, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 205卷

关键词：

1,2,4-Triazole; Molecular interactions; Enzyme inhibitors; Hybrid compounds; Pharmacological activities; Structure-activity relationship; FALCIPARUM DIHYDROOROTATE DEHYDROGENASE; ANTICONVULSANT ACTIVITY EVALUATION; TRIAZOLE ANTIFUNGAL DERIVATIVES; POTENTIAL ANTIMICROBIAL AGENTS; BEARING BRIDGEHEAD NITROGEN; IN-VITRO EVALUATION; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ANTIINFLAMMATORY ACTIVITY; ANTIBACTERIAL ACTIVITY;

D O I：

10.1016/j.ejmech.2020.112652

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. along with structure-activity relationship. The comprehensive compilation of work carried out in the last decade on 1,2,4-triazole nucleus will provide inevitable scope for researchers for the advancement of novel potential drug candidates having better efficacy and selectivity. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：46

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