Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents

被引：36

作者：

Abu-Hashem, Ameen A. ^{[1
,2
]}

Hussein, Hoda A. R. ^{[1
]}

Abu-zied, Khadeja M. ^{[1
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Heterocycl Unit, Giza 12622, Egypt

[2] Jazan Univ, Dept Chem, Fac Sci, Jezan 2097, Saudi Arabia

来源：

MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 01期

关键词：

Triazolopyrimidines; Benzohydrazide; Isothiocyocyanate; Antimicrobial activity; ANTITUMOR-ACTIVITY; DERIVATIVES; ANTIOXIDANT; COMPLEXES; TRIAZOLE;

D O I：

10.1007/s00044-016-1733-5

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

7-aminopyrimidin-5(1H)-one (5) was utilized as a starting material for the preparation of new, Schiff bases (13-19), amides 23, 24, imide 25, as well as thiourea derivatives 30-33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compounds were based upon compatible microanalytical and spectroscopic measurement. Biological evaluation indicated that compounds 23, 31, 33, 32, and 30 possess promising antimicrobial activities. </InlineMediaObject>.

引用

页码：120 / 130

页数：11

共 27 条

[1]

Synthesis, analgesic, and antiparkinsonian profiles of some pyridine, pyrazoline, and thiopyrimidine derivatives [J].

Abdel-Latif, Nehad A. ;

Sabry, Nermien M. ;

Mohamed, Ashraf M. ;

Abdulla, Mohamed M. .

MONATSHEFTE FUR CHEMIE, 2007, 138 (07) :715-724

[2]

Synthetic utility of bifunctional thiophene derivatives and antimicrobial evaluation of the newly synthesized agents [J].

Abu-Hashem, Ameen A. ;

Abu-Zied, Khadiga M. ;

El-Shehry, Mohamed F. .

MONATSHEFTE FUR CHEMIE, 2011, 142 (05) :539-545

[3]

Synthesis of New Pyrazole, Triazole, and Thiazolidine-Pyrimido [4, 5-b] quinoline Derivatives with Potential Antitumor Activity [J].

Abu-Hashem, Ameen Ali ;

Aly, Ahmed S. .

ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (03) :437-445

[4]

Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines Derivatives [J].

Abu-Hashem, Ameen Ali ;

Youssef, Mohamed M. ;

Hussein, Hoda A. R. .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2011, 58 (01) :41-48

[5]

Thieno[2,3-d]pyrimidines in the Synthesis of New Fused Heterocyclic Compounds of Prospective Antitumor and Antioxidant Agents (Part II) [J].

Aly, Ashraf A. ;

Ramadan, Mohamed ;

Mohamed, Ashraf M. ;

Ishak, Esam A. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (05) :1009-1018

[6]

PYRIDO[2,3-D]PYRIMIDINES .4. SYNTHETIC STUDIES LEADING TO VARIOUS OXOPYRIDO[2,3-D]PYRIMIDINES [J].

BROOM, AD ;

SHIM, JL ;

ANDERSON, GL .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (07) :1095-1099

[7]

Synthesis, antifungal activity and CoMFA analysis of novel l,2,4-triazolo[1,5-a]pyrimidine derivatives [J].

Chen, Qiong ;

Zhu, Xiao-Lei ;

Jiang, Li-Li ;

Liu, Zu-Ming ;

Yang, Guang-Fu .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (03) :595-603

[8]

Cruickshank R., 1975, Medicinal microbiology, V12th, P196

[9]

ANTIMICROBIAL ACTIVITY OF 8-DEAZAFOLIC ACID [J].

DEGRAW, JI ;

KISLIUK, RL ;

GAUMONT, Y ;

BAUGH, CM .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (04) :470-471

[10]

Deyanov B, 1991, J PHARM CHEM, V25, P248

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