Synthesis, analgesic, and antiparkinsonian profiles of some pyridine, pyrazoline, and thiopyrimidine derivatives

A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene (R) and Benzatropine (R) as reference drugs. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties for synthesized compounds are reported.