Sequential Phosphine-Catalyzed, Nucleophilic Thiol-Ene/Radical-Mediated Thiol-Yne Reactions and the Facile Orthogonal Synthesis of Polyfunctional Materials

被引：247

作者：

Chan, Justin W. ^{[1
]}

Hoyle, Charles E. ^{[1
]}

Lowe, Andrew B. ^{[1
]}

机构：

[1] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 16期

关键词：

CLICK CHEMISTRY; POLYMERS; FUNCTIONALIZATION; HYDROTHIOLATION; ALKYNES;

D O I：

10.1021/ja8099135

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of highly efficient sequential thiol-ene/thiol-yne reactions conducted in an orthogonal manner is presented and its broad application in the synthesis of polyfunctional materials demonstrated. The anionic chain mechanism of the phosphine-mediated thiol-ene reaction is highlighted, as is the radical-mediated thiol-yne reaction. Kinetic data for a model reaction are presented, followed by a discussion of the synthesis of a range of materials with diverse functionality, including an example of potential biomedical significance.

引用

页码：5751 / +

页数：4

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