Local caspase activity directs engulfment of dendrites during pruning

被引：278

作者：

Williams, Darren W. ^{[1
]}

Kondo, Shu

Krzyzanowska, Agnieszka

Hiromi, Yasushi

Truman, James W.

机构：

[1] Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England

[2] Univ Washington, Dept Biol, Seattle, WA 98195 USA

[3] Natl Inst Genet, CREST, Japan Sci & Technol Agcy, Shizuoka 4118540, Japan

[4] SOKENDAI, Dept Genet, Shizuoka 4118540, Japan

[5] Jikei Univ, Sch Med, Div Morphol & Organogenesis, Inst DNA Med, Tokyo 1058461, Japan

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nn1774

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons.

引用

页码：1234 / 1236

页数：3

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