Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

被引：276

作者：

Nakano, Hideki ^{[1
,2
,3
]}

Lin, Kaifeng Lisa ^{[2
]}

Yanagita, Manabu ^{[1
]}

Charbonneau, Chantal ^{[1
]}

Cook, Donald N. ^{[3
]}

Kakiuchi, Terutaka ^{[4
]}

Gunn, Michael D. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

[3] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Res Triangle Pk, NC USA

[4] Toho Univ, Sch Med, Dept Immunol, Tokyo, Japan

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 04期

基金：

日本学术振兴会; 美国国家卫生研究院;

关键词：

MICE LACKING EXPRESSION; STEADY-STATE; IN-VIVO; MONOCYTE RECRUITMENT; AIRWAY INFLAMMATION; ADAPTIVE IMMUNITY; CHEMOKINES CCL19; ORGAN CHEMOKINE; KNOCKOUT MICE; ANTIGEN;

D O I：

10.1038/ni.1707

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper type 1 (T(H)1)- polarized immune responses, which confer protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues. Here we found after viral infection or immunization, inflammatory monocytes were recruited into lymph nodes directly from the blood to become CD11c(+) CD11b(hi)Gr-1(+) inflammatory DCs, which produced abundant interleukin 12p70 and potently stimulated T(H)1 responses. This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7. Thus, the accumulation of inflammatory DCs and T(H)1 responses were much lower in Ccr2(-/-) mice, were preserved in Ccl2(-/-) mice and were relatively higher in CCL19-CCL21-Ser-deficient plt mutant mice, in which all other lymph node DC types were fewer in number. We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses.

引用

页码：394 / 402

页数：9

共 44 条

[41] Monocytes give rise to mucosal, but not splenic, conventional dendritic cells [J].