HLA Class II peptide-binding and autoimmunity

被引：52

作者：

Gebe, JA ^{[1
]}

Swanson, E ^{[1
]}

Kwok, WW ^{[1
]}

机构：

[1] Virginia Mason, Benaroya Res Inst, Seattle, WA 98101 USA

来源：

TISSUE ANTIGENS | 2002年 / 59卷 / 02期

关键词：

D O I：

10.1034/j.1399-0039.2002.590202.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The HLA class 11 locus is located in the 6p21.3 region on the short arm of chromosome 6 and encompasses approximately 700kb. It consists of over 30 gene loci including the major class II structural genes DP, DQ and DR. While autoimmune disease correlates to specific DP. DQ or DR alleles have been documented, due to the strong linkage disequilibrium between the different HLA alleles, especially between the DR and DQ, the precise identification of susceptible MHC alleles for a number of autoimmune diseases remains elusive.

引用

页码：78 / 87

页数：10

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