Mismatch-binding ligands function as a molecular glue for DNA

被引：61

作者：

Peng, Tao ^{[1
]}

Dohno, Chikara ^{[1
]}

Nakatani, Kazuhiko ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Dept Regulatory Bioorgan Chem, Ibaraki 5670047, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 34期

关键词：

DNA; hybridization; mass spectrometry; nucleotides;

D O I：

10.1002/anie.200601190

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A sticky end: Two DNA strands that produce three contiguous mismatches (5′-TGG-3′/5′-TGG-3′ sequence) do not hybridize spontaneously, but are adhered by the mismatch-binding ligand naphthyridine carbamate dimer (NC; see picture, red rectangles: naphthyridine rings). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5623 / 5626

页数：4

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