Efflux in Fungi: La Piece de Resistance

被引：179

作者：

Coleman, Jeffrey J. ^{[1
]}

Mylonakis, Eleftherios

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

PLOS PATHOGENS | 2009年 / 5卷 / 06期

关键词：

BINDING-CASSETTE TRANSPORTER; MAJOR FACILITATOR SUPERFAMILY; BIOSYNTHETIC GENE-CLUSTER; MESSENGER-RNA LEVELS; CANDIDA-ALBICANS; ABC TRANSPORTER; MULTIDRUG-RESISTANCE; FLUCONAZOLE RESISTANCE; DRUG-RESISTANCE; AZOLE RESISTANCE;

D O I：

10.1371/journal.ppat.1000486

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in particular ATP-binding cassette transporters and transporters of the major facilitator superfamily. Members of these two superfamilies remove many toxic compounds by coupling transport with ATP hydrolysis or a proton gradient, respectively. Fungal genomes encode a plethora of members of these families of transporters compared to other organisms. In this review we discuss the role these two fungal superfamilies of transporters play in virulence and resistance to antifungal agents. These efflux transporters are responsible not only for export of compounds involved in pathogenesis such as secondary metabolites, but also export of host-derived antimicrobial compounds. In addition, we examine the current knowledge of these transporters in resistance of pathogens to clinically relevant antifungal agents.

引用

页数：7

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