Parallel synthesis of 1,2,4-trisubstituted imidazoles via N-alkyl-N-(β-keto)amides using a carbazate linker

被引：28

作者：

Cobb, JM ^{[1
]}

Grimster, N ^{[1
]}

Khan, N ^{[1
]}

Lai, JYQ ^{[1
]}

Payne, HJ ^{[1
]}

Payne, LJ ^{[1
]}

Raynham, T ^{[1
]}

Taylor, J ^{[1
]}

机构：

[1] Millennium Pharmceut Ltd, Cambridge CB1 6ET, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 42期

关键词：

N-alkyl-N-(beta-keto)amide; 1,2,4-trisubstituted imidazole; carbazate linker; solid phase synthesis;

D O I：

10.1016/S0040-4039(02)01810-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(beta-keto)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(beta-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solution Using NH4OAc led to the preparation of 1400 1,2.4-trisubstituted imidazoles. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：7557 / 7560

页数：4

共 11 条

[1]

Adams J L, 1999, Curr Opin Drug Discov Devel, V2, P96

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