学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Natural killer T cells: drivers or passengers in preventing human disease?

被引：60
作者：
Berzins, Stuart P. [1 ,2 ,3 ]
Ritchie, David S. [4 ,5 ,6 ]
机构：
[1] Federat Univ, Sch Hlth Sci, Ballarat, Vic 3350, Australia
[2] Fiona Elsey Canc Res Inst, Ballarat, Vic 3350, Australia
[3] Univ Melbourne, Peter Doherty Inst, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[4] Royal Melbourne Hosp, Dept Clin Hematol, Parkville, Vic 3010, Australia
[5] Royal Melbourne Hosp, Bone Marrow Transplant Serv, Parkville, Vic 3010, Australia
[6] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3050, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 09期
关键词：
INVARIANT NKT CELLS; AUTOIMMUNE DIABETES-MELLITUS; LUNG-CANCER PATIENTS; ANTIGEN IN-VIVO; DENDRITIC CELLS; NOD MICE; TUMOR-IMMUNITY; AIRWAY HYPERREACTIVITY; MULTIPLE-MYELOMA; PERIPHERAL-BLOOD;
D O I：
10.1038/nri3725
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
071005 [微生物学]; 100108 [医学免疫学];
摘要：
Natural killer T (NKT) cells are credited with regulatory roles in immunity against cancers, autoimmune diseases, allergies, and bacterial and viral infections. Studies in mice and observational research in patient groups have suggested that NKT cell-based therapies could be used to prevent or treat these diseases, yet the translation into clinical settings has been disappointing. We support the view that NKT cells have regulatory characteristics that could be exploited in clinical settings, but there are doubts about the natural roles of NKT cells in vivo and whether NKT cell defects are fundamental drivers of disease in humans. In this Opinion article, we discuss the uncertainties and opportunities regarding NKT cells in humans, and the potential for NKT cells to be manipulated to prevent or treat disease.
引用
收藏
页码：640 / 646
页数：7
相关论文
共 125 条
[1]
CD4+ invariant T-cell-receptor plus natural killer T cells in bronchial asthma. [J].
Akbari, O ;
Faul, JL ;
Hoyte, EG ;
Berry, GJ ;
Wahlström, J ;
Kronenberg, M ;
DeKruyff, RH ;
Umetsu, DT .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (11) :1117-1129
[2]
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].
Akbari, O ;
Stock, P ;
Meyer, E ;
Kronenberg, M ;
Sidobre, S ;
Nakayama, T ;
Taniguchi, M ;
Grusby, MJ ;
DeKruyff, RH ;
Umetsu, DT .
NATURE MEDICINE, 2003, 9 (05) :582-588
[3]
Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].
Baxter, AG ;
Kinder, SJ ;
Hammond, KJL ;
Scollay, R ;
Godfrey, DI .
DIABETES, 1997, 46 (04) :572-582
[4]
NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells [J].
Beaudoin, L ;
Laloux, V ;
Novak, J ;
Lucas, B ;
Lehuen, A .
IMMUNITY, 2002, 17 (06) :725-736
[5]
Plasmacytoid dendritic cells license regulatory T cells, upon iNKT- cell stimulation, to prevent autoimmune diabetes [J].
Beaudoin, Lucie ;
Diana, Julien ;
Ghazarian, Liana ;
Simoni, Yannick ;
Boitard, Christian ;
Lehuen, Agnes .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (05) :1454-1466
[6]
Lower TCR repertoire diversity in Traj18-deficient mice [J].
Bedel, Romain ;
Matsuda, Jennifer L. ;
Brigl, Manfred ;
White, Janice ;
Kappler, John ;
Marrack, Philippa ;
Gapin, Laurent .
NATURE IMMUNOLOGY, 2012, 13 (08) :705-706
[7]
The biology of NKT cells [J].
Bendelac, Albert ;
Savage, Paul B. ;
Teyton, Luc .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :297-336
[8]
Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies [J].
Berzins, SP ;
Kyparissoudis, K ;
Pellicci, DG ;
Hammond, KJ ;
Sidobre, S ;
Baxter, A ;
Smyth, MJ ;
Kronenberg, M ;
Godfrey, DI .
IMMUNOLOGY AND CELL BIOLOGY, 2004, 82 (03) :247-252
[9]
Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples [J].
Berzins, SP ;
Cochrane, AD ;
Pellicci, DG ;
Smyth, MJ ;
Godfrey, DI .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1399-1407
[10]
Presumed guilty: natural killer T cell defects and human disease [J].
Berzins, Stuart P. ;
Smyth, Mark J. ;
Baxter, Alan G. .
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) :131-142
12345678910