Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies

被引：36

作者：

Berzins, SP ^{[1
]}

Kyparissoudis, K ^{[1
]}

Pellicci, DG ^{[1
]}

Hammond, KJ ^{[1
]}

Sidobre, S ^{[1
]}

Baxter, A ^{[1
]}

Smyth, MJ ^{[1
]}

Kronenberg, M ^{[1
]}

Godfrey, DI ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3181, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2004年 / 82卷 / 03期

关键词：

blood; natural killer T cell; NOD mouse; tolerance; type; 1; diabetes;

D O I：

10.1046/j.1440-1711.2004.01238.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the diabetes-prone NOD mouse, there is a proven association between a systemic deficiency of NKT cells and the onset of type 1 diabetes. Numerous reports of similar defects within the NKT cell compartment of human type 1 diabetes patients suggested NKT cell levels might be a valuable predictor of susceptibility and could provide a target for therapeutic intervention. Two recent studies, however, found no association between type 1 diabetes and blood NKT cell levels in humans and consequently rejected a link between the onset of diabetes and NKT cell deficiency. This cast considerable doubts on the potential for NKT cell-based clinical applications and challenged the validity of the NOD mouse as a model of human type 1 diabetes. We now report that NKT cell levels in blood are a poor representation of those in other organs. Strikingly, systemic NKT cell deficiencies were identified in NOD mice with normal, or even raised, blood levels. This re-establishes the correlation between NKT cell deficiency and type 1 diabetes and raises important questions regarding the assaying of NKT cell levels in humans.

引用

页码：247 / 252

页数：6

共 31 条

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