A prospective study of prognostic value of type IV collagenase activity in colorectal cancer tissue

被引：12

作者：

Ambiru, S

Miyazaki, M

Ito, H

Nakagawa, K

Shimizu, H

Nukui, Y

Nozawa, S

Okuno, A

Yoshitomi, H

Nakajima, N

机构：

[1] First Department of Surgery, Chiha University, School of Medicine, Chuo-ku, Chiba

[2] First Department of Surgery, Chiba University, School of Medicine, Chuo-ku, Chiba 260

来源：

DIGESTIVE DISEASES AND SCIENCES | 1997年 / 42卷 / 08期

关键词：

colorectal cancer; prognostic factor; type IV collagenase;

D O I：

10.1023/A:1018801229372

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The purpose of this prospective study was to evaluate the prognostic value of the type IV collagenase (IVase) activity in colorectal cancer tissue on disease-free and overall survival in 31 colorectal cancer patients. The clinicopathologic factors studied for prognostic value were age, tumor location, tumor differentiation; preoperative serum levels of carcinoembryonic antigen, Dukes' stage, and IVase activity in colorectal cancer tissue. IVase activities in colorectal cancer tissue were significantly higher in the group of patients with recurrences than in the group without recurrences (P = 0.019). Patients with high IVase activity in colorectal dancer tissue had a significantly shorter disease-free survival (P = 0.0016) and overall survival (P = 0.022) time than those with low IVase activity. Univariate and multivariate analysis showed that significant prognostic factors for disease-free survival were Dukes' stage (P = 0.029, P = 0.046, respectively) and IVase activity status (P = 0.0016, P = 0.0026, respectively). With respect to overall survival, only IVase activity status provided significant Predictive value in multivariate analysis (P = 0.041). This prospective study suggests that IVase activity is a valuable prognostic factor in colorectal cancer patients.

引用

页码：1660 / 1665

页数：6

共 38 条

[21] SUPPRESSION OF THE TUMORIGENIC AND METASTATIC ABILITIES OF MURINE B16-F10 MELANOMA-CELLS IN-VIVO BY THE OVEREXPRESSION OF THE TISSUE INHIBITOR OF THE METALLOPROTEINASES-1 [J].